Serum Concentration of Valproic Acid after Rectal Administration
نویسندگان
چکیده
منابع مشابه
Effect of UGT2B7 genetic variants on serum valproic acid concentration.
OBJECTIVE To investigate the effect of UGT2B7 A268G and UGT2B7 G211T genetic polymorphism on serum drug concentration of valproic acid (VPA). METHODS Genetic polymorphisms of UGT2B7 A268G and UGT2B7 G211T were tested in 248 epileptic patients by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Data including basic information, epilepsy type, times and doses of dr...
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Valproic acid (VPA) is an established drug in the long-term therapy of seizure disorders. Recently, VPA has been associated with anticancer activity, an effect thought to be mediated through the inhibition of cellular histone deacetylase 1. We investigated the effect of various doses of VPA (0, 1.2, and 5.0 mmol/L) administered either acutely or chronically on histone acetylation, p21 gene expr...
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The pharmacokinetics of lidocaine deals with the measurement of lidocaine concentration in the blood and its changes over time. The toxicity of lidocaine is a function of its peak plasma concentration, which in turn depends on several factors including total dose and rates of systemic absorption and elimination. The aim of the study was to assess serum levels of lidocaine after a single shot ep...
متن کاملHallucinations after withdrawal of valproic acid.
We report 2 children with a history of epilepsy in whom valproic acid (VPA) withdrawal was identified as a potential cause of hallucinations. After a restart of VPA, the hallucinations disappeared. We suggest mechanisms for the occurrence of the hallucinations and a possible control of a predisposition to hallucinations by VPA.
متن کاملThe developmental gross morphology of pancreas in chick embryo after prenatal administration of valproic acid.
OBJECTIVE To determine the effects of prenatal administration of valproic acid on the developmental gross morphology of pancreas in chick embryo. STUDY DESIGN Experimental study. PLACE AND DURATION OF STUDY Anatomy Department, Regional Centre, College of Physicians and Surgeons, Islamabad, from February 2010 to February 2011. METHODOLOGY An experimental group-A and control group-B, compri...
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ژورنال
عنوان ژورنال: Neurologia medico-chirurgica
سال: 1988
ISSN: 0470-8105,1349-8029
DOI: 10.2176/nmc.28.473